How do microplastics damage ovarian granulosa cells?

Microplastics have been shown to trigger cell death in ovarian granulosa cells through two distinct pathways: apoptosis and pyroptosis. Granulosa cells surround and nourish developing eggs within ovarian follicles, providing essential hormones and growth factors. When microplastics infiltrate the follicular environment, they generate reactive oxygen species that activate programmed cell death, robbing the developing oocyte of critical support.

The loss of granulosa cells has cascading consequences for fertility. With fewer functional granulosa cells, follicles produce less estrogen and fewer growth factors, leading to impaired ovulation and lower egg quality. Women exposed to higher levels of microplastics have been found to have fewer viable follicles during IVF retrieval cycles. Pyroptosis, an inflammatory form of cell death, also releases inflammatory signals that can further damage surrounding ovarian tissue.

Because textile fibers represent a substantial share of the microplastics humans absorb daily, the clothing and bedding you choose has a direct impact on your cumulative exposure. Natural fibers like organic cotton, Tencel, and linen do not shed persistent plastic fragments. ONDU connects you with brands like Tripulse and Mate the Label whose products are designed to be safe for your body and your reproductive health.